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Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents: A Critical Assessment of NMR and Biophysical Studies - PMC

For explaining the long-distance PRE effects, which are incompatible with a single structure, the authors invoke the existence of large-scale motions (cf., the discussion on PRE effects in UCP2, Figure 10)

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Hitting one or two hallmarks is not a strategy

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