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Red blood cells contain relatively high concentrations of reduced glutathione (GSH), a sulfhydryl-containing tripeptide (glutamylcysteinylglycine) which functions as an intracellular reducing agent that protects cells against oxidant injury

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While the roles of DNA DSBs, oxidative stress, and chronic inflammation are well understood, a unified framework that incorporates epigenetic regulation, mitochondrial dysfunction, and stromal-immune interactions is still lacking