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There are multiple interesting PPIs in the Wnt signaling pathway, notably β-catenin/TCF and β-catenin/Bcl9, for which there are several reported small-molecule 201,202 and macrocyclic peptide binders (particularly stapled peptides), 203 although these were generally obtained from rational structure-based design rather than NELS campaigns
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whereas the serum DHEAS in young males is much higher than in females, after menopause/andropause, it is very similar
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