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This dimerization allows Nrf2 to bind to antioxidant response elements (AREs), activating the transcription of a variety of genes encoding cytoprotective, antioxidant, and phase II detoxification proteins [39,40,41,42]

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Chemical investigations also revealed the presence of triterpenoids (lanostane and cycloartane-type triterpenoids and nortiterpenoids), organic acids (citric, fumaric, malic, and tartaric acids), phenolic acids (chlorogenic, gentisic, p-hydroxybenzoic, p-coumaric, protocatechuic, syringic, and salicylic acids) [7,8], flavonoids (quercetin, isoquercitrin, rutin, and hyperoside) [8], vitamins C and E, phytosterols, and bioelements (Cr, Cu, Co, Ca, Mg, Fe, Zn, Mn, B, Ni,) [1,7,9]