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This was established by Baar and colleagues, who designed the FOXO4-DRI peptide to disrupt the FOXO4–p53 interaction, causing nuclear exclusion of p53 and apoptosis in senescent cells (Cancer Discovery summary of the 2017 Cell paper)

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[198 199] For example, severe hypertension can result in pulmonary edema (more common in patients with preserved LVEF), requiring urgent treatment to reduce blood pressure