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According to StatPearls, fluoxetine itself has a half-life of about two to four days, and its active metabolite norfluoxetine persists for seven to nine days
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Recent work shows that chronic corticosterone treatment also decreases expression of caldesmon, an F-actin-stabilizing molecule, increasing F-actin turnover in dendritic spines and resulting in smaller, more unstable spines 82
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