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We did not observe an association with the Parkinson disease genes synuclein, alpha (non A4 component of amyloid precursor) ( SNCA ) (Ross et al., 2011), leucine-rich repeat kinase 2 ( LRRK2 ) (Clark et al., 2010a), glucocerebrosidase ( GBA ) (Clark et al., 2010a), or microtubule-associated protein tau ( MAPT ) (Clark et al., 2014), nor did we identify pathogenic repeat expansions in the 10 common degenerative loci ( SCA-1 ( ATXN1 ) , SCA-2 ( ATXN2 ) , SCA-3 ( ATXN3 ) , SCA-6 ( CACNA1A ) , SCA-7 ( ATXN7 ) , SCA-8 ( ATXN8OS ) , SCA-10 ( ATXN10 ) , SCA-12 ( PPP2R2B ) , SCA-17 ( TBP ), and DRPLA ( ATN1 ) or FRAXA (unpublished results) (Clark and Louis, 2015)

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Moreover, accumulating evidence supports the view that HPA axis activity is enhanced in individuals with insomnia exhibit excessive arousal [121]