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Importantly, REDEFINE 1 also showed that a significant proportion of participants achieved ≥25% body weight reduction — a threshold that, in clinical terms, represents the kind of weight loss previously achievable only through bariatric surgery

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4.2.2 Methodological limitations 4.2.2.1 Study design challenges A PCB occupational exposure study involving 89 workers exemplifies common methodological limitations that can obscure true exposure-response relationships