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Decreased Nrf2 activity in conditions such as aging or chronic NI leads to the accumulation of oxidative damage and the predominance of NF-κB activity [45]

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By contrast, GSTK1 has a bacterial disulphide-bond-A (DsbA)-like thioredoxin domain (pfam01323) and is a member of a diverse set of proteins with a thioredoxin-like structure (pfam00085) [23]