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275 Further, a novel Wnt inhibitor, SM04690 were proved to effectively relieve the pain of severe symptomatic knee osteoarthritis (OA) and appeared safe and well tolerated through phase I/II clinical trial

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One of the targets is the synaptic vesicle glycoprotein 2C (SV2C), which contributes to dopamine homeostasis and is being investigated for its potential in restoring dopaminergic signaling [182]