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In the present cohort of adolescents, we found that females exhibited a higher cortisol/11-deoxycortisol ratio than males, a difference that mediated in part the higher levels of internalizing symptoms observed in females, suggesting a causal effect of HPA-axis function on internalizing symptoms

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No published human pharmacokinetic data exists for either route, so oral bioavailability comparisons between the two are extrapolation, not measurement