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Research demonstrates that IGF-1 LR3 activates the same downstream pathways as native IGF-1, primarily the PI3K/Akt/mTOR and Ras/MAPK/ERK cascades, but with greater potency due to its prolonged receptor availability
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A role for the androgen metabolite, 5Ξ±-androstane-3Ξ²,17Ξ²-diol, in modulating oestrogen receptor Ξ²-mediated regulation of hormonal stress reactivity
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