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The first generation complex, Bamet-H2 (Chart 4), was simply prepared by allowing sodium cholylglycinate to react with tetrachloroplatinate(II)
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Together these results suggest that ORF3a induces mROS production to activate HIF-1α, which in turn triggers a shift in cellular metabolism to favor glycolysis, resulting in increased viral replication and transcription of pro-inflammatory cytokines
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