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Most people begin noticing changes within four to six weeks of consistent daily use, though significant fat reduction and body composition improvements may take three to six months

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The identical phase III, randomized, double-blind trials ULTIMATE I and II enrolled 1094 patients with relapsing-remitting multiple sclerosis who had two or more relapses in the prior 2 years, one relapse in the prior year, or one or more Gd+ lesions (98)