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Activation of these signaling pathways promotes the release of pro-inflammatory cytokines, including interleukin (IL)-6, IL-1β, and tumor necrosis factor-alpha (TNF-α), which compromise the integrity of the endothelial glycocalyx, increase glomerular capillary permeability, and promote microalbuminuria—an early hallmark of diabetic renal injury (26, 30–32)
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