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These inherent pharmacokinetic and pathophysiological gaps demand careful human-equivalent dosing and long-term translational studies before antioxidant benefits can be claimed ( 5.2 Clinical trials of natural antioxidants in DN Although rodent models provide mechanistic insights, they often oversimplify the chronic, multifactorial nature of human diabetes

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Impaired heme production, leading to blood cells with less oxygen-carrying hemoglobin and, over time, microcytic anemia