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Disclosure of interest: No conflict of interest E-Posters - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.02 - GENETICS, ‘OMICS AND BIOMARKERS P2577 - ESOC25-782 LARGE ARTERY ATHEROSCLEROTIC STROKE RELATED SNP VARIANTS ASSOCIATED WITH STROKE RISK FACTORS AND MECHANISMS IN SYMPTOMATIC INTRACRANIAL ATHEROSCLEROSIS Yue Gu 1 , Yifu Wang 2 , Qiaoshu Wang 2 , Xinyi Leng 1 1 Department of Medicine and Therapeutics, the Chinese University of Hong Kong, Hong Kong, Hong Kong, 2 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Background and Aims: Previous studies have identified numerous risk loci for large artery atherosclerotic stroke (LAAS)