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Rather than acting as a direct sleep trigger, DSIP has been hypothesized to modulate thresholds of neural excitability, thereby contributing to transitions between vigilance states

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· These drugs are part of an emerging class of nutrient-stimulated hormone-based therapeutics that act as incretin mimetics, targeting G-protein–coupled receptors such as GLP-1, glucose-dependent insulinotropic polypeptide (GIP), and glucagon, which are crucial in body fat and energy balance regulation