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The main precautionary note for GHK-Cu concerns individuals with known copper metabolism disorders or Wilson’s disease, for whom any additional copper loading, including from GHK-Cu, would be contraindicated

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Similarly, in the field experiments where moderate and high wheat planting density (above 450 × 10 4 seedlings per ha) were shown to significantly decrease the yield, 1000-grain weight, and grain number per spike, sprayed spermidine at anthesis managed to increase both starch and sucrose levels, by affecting sucrose synthase and ADP-glucose pyrophosphorylase activities, and to enhance yield 71