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Reasons for exclusion included: one study not retrieved (full text unavailable), nine studies lacking a placebo control group, three studies with a treatment duration of less than 12 weeks, five studies that were not RCTs, four studies without relevant outcomes, two studies with insufficient data, one meeting abstract, and two studies focused on maximum tolerated doses

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Evidence from topical products, laboratory studies, or preclinical models should be distinguished from evidence supporting injectable use