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For example, in Caco-2 cells, there was about one-fold decrease in the apical efflux of hesperetin glucuronide when Ko143 (5 μM) was used as BCRP inhibitor (Brand et al., 2008)

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The researchers showed that FOXO4-DRI treatment induced apoptosis specifically in senescent chondrocytes while sparing healthy proliferating cells, confirming the selectivity mechanism described in the original Baar et al