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11,12 This model proposes that the RBD-PD subtype follows a “body-first” trajectory, in which α-synuclein pathology originates in the peripheral or enteric nervous system (ENS) and subsequently ascends via the vagus nerve to the brainstem, particularly the locus coeruleus/subcoeruleus complex, which is considered one of the core pathological nuclei involved in RBD

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