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Starting too early may interfere with necessary initial inflammatory processes that initiate healing

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The two-receptor approach is studied because GHRH and GHS-R1a signaling activate complementary but distinct intracellular pathways — GHRHR primarily through Gs/cAMP/PKA, GHS-R1a primarily through Gq/PLC/IP3/Ca²⁺ — making the dual-agonist approach a useful research tool for studying somatotrope cell biology comprehensively