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Consistent with this, mice homozygous for a spontaneous null mutation of the gene showed no defects in growth or DNA replication (Rogers et al., 2004), and mice zygotically homozygous-null for either the gene encoding cytosolic Trx1 (Matsui et al., 1996) or the gene encoding cytosolic TrxR1 (Bondareva et al., 2007
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