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The genetic factors are related to gene defects on HLA regions that code the histocompatibility complex, creating autoimmune response

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The Marmarou WDI is distinct from Shohami, Feeny, or Shapira’s models, as it simulates diffuse acceleration injury, representing a diffuse brain injury seen in falls or car accidents (Marmarou et al., 1994), resulting in mild to severe hemorrhage, cell loss, diffuse axonal injury, and astrogliosis (Albert-Weissenberger et al., 2012)