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In addition, TM regional heterogeneity and disease-associated niche alteration (such as in POAG eyes with pronounced ECM remodeling) may require combinatorial strategies (pairing cell replacement with ECM-modulating enzymes or gene-editing of resident cells) to achieve durable restoration (78–82)

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Evidence from North Carolina Evaluations of the North Carolina “Healthy Opportunity Pilots” waiver approved by the first Trump administration show lower costs over time and largely positive outcomes