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Telgmann L, Wehe CA, Künnemeyer J, Bülter AC, Sperling M, Karst U

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reported that in addition to its canonical function as a metabolic enzyme in the mitochondrial TCA, the PDC was able to translocate to the nucleus to during cell-cycle progression, producing a nuclear pool of acetyl-CoA from pyruvate and promoting histone acetylation and E2F1 expression (Sutendra et al., 2014)