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Circulation Research 98: 1352–1364

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The topical-route human evidence consists of the Mulder 1994 multicenter RCT in diabetic neuropathic ulcers (industry-sponsored, evaluator-blinded) [11] , the Leyden 2002 AAD conference abstract (never published in a peer-reviewed journal), and the Miller 2006 split-face CO2-laser study, which reported no statistically significant benefit in blinded objective measures of erythema or wrinkle measurement [12]