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The latter is however sufficient to lead to a substantial CS in presence of verapamil as already shown with other potent CS agents able to induce a strong CS while GSH efflux stimulation ranged between 34 to 78% 18

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Firstly, the main strength is the long study follow-up (15 months), which allows for gathering information about potential changes in patients’ QoL in response to long-term ALC treatment, usually not be easily detectable in studies with shorter observation periods