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Mechanistically, miR-148b-3p directly targeted the delta-like canonical notch ligand 4/neurogenic locus notch homolog protein 1 (DLL4/Notch1) signaling axis, and knockdown of either DLL4 or Notch1 phenocopied the protective effects of exosome treatment, identifying this pathway as a key regulator of ischemia-induced microglial activation (238)

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