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Keywords: vitamin B 12 , traumatic brain injury, endoplasmic reticulum stress, microtubule, myelin Introductions Traumatic brain injury (TBI) is commonly found following traffic accidents in adults or perinatal asphyxia in newborns, which causes brain swelling with an increase in intracranial pressure and a subsequent decrease in cerebral perfusion leading to ischaemia (Fink et al., 2012)