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The 2021 American College of Cardiology (ACC)/American Heart Association (AHA)/and Society for Cardiovascular Angiography and Interventions (SCAI) Guideline for Coronary Artery Revascularization recommends 100–325 mg aspirin daily initiated within six hours postoperatively and then continued indefinitely to reduce the occurrence of vein graft closure and adverse cardiovascular events (class of recommendation [COR] I, level of evidence [LOE] A) ( Dual antiplatelet therapy P2Y 12 receptor inhibitors inhibit binding of adenosine diphosphate (ADP) to its platelet P2Y 12 receptor, preventing the ADP-mediated activation of the GPIIb/IIIa complex and subsequent platelet aggregation ( 12 inhibitor to aspirin [dual antiplatelet therapy (DAPT)] leads to enhanced platelet inhibitory effects ( An overview of oral P2Y 12 inhibitors is presented in Table 1

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