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Furthermore, the sympathetic nervous system, through catecholamines and its peripheral receptors, together with the neurotransmitter serotonin, participates in skin pigmentation and has been observed to be involved in the development of vitiligo [147]

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Therefore, although some oligonucleotide products targeting NNMT have shown effectiveness in vitro and in animal experiments, to date, no oligonucleotide products targeting NNMT have been used in clinical trials