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Chronic MP infection induces pathological vascular remodeling and microenvironmental hypoxia in the lungs, which can upregulate expression of multiple pro-fibrotic genes (such as VEGF, PDGF, and TGF-β) (180) or promote vascular remodeling and fibrosis by regulating expression of angiopoietin-1, IL-6, MMP2, collagen I, and collagen III through the calpain-1-HIF-1α axis (181)

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[DOI] [PubMed] [Google Scholar] 64.Schreiner J, Thommen DS, Herzig P, Bacac M, Klein C, Roller A, Belousov A, Levitsky V, Savic S, Moersig W, et al