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Collagen IV and V, heparan sulfate proteoglycans, and laminin are mainly located in basement membranes or basal lamina, which is dense with vascular endothelial cells and glial cells lining axon bundles in the optic nerve head 50,51

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Adipose-resident cells (adipocytes, ASCs), their secretome (adipokines, cytokines, extracellular vesicles), and adipose-remodeled ECM collaborate to (i) prime distant organs, (ii) supply metabolic substrates that sustain survival under stress, and (iii) modulate immunity to favor metastatic seeding and regrowth