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The conversion of chorismic acid to phenazine-1-carboxylic acid (PCA) involves seven, phenazine-specific, highly conserved, enzyme-encoding genes, namely, phzA , phzB , phzC , phzD , phzE , phzF , and phzG , that are comprised within two homologous core biosynthetic loci viz., phzA 1 B 1 C 1 D 1 E 1 F 1 G 1 ( phz1 ) and phzA 2 B 2 C 2 D 2 E 2 F 2 G 2 ( phz2 ) operons (Sterritt et al
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However, consistent with observations from acrolein-treated cells, phosphorylation of MLKL remained unchanged in tumors from mice treated with cyclophosphamide, with or without hydralazine (Fig
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