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Since the NNMT inhibitor 5-amino-1MQ significantly reduced intracellular 1-MNA concentrations, we hypothesized that NNMT inhibition in adipocytes would increase intracellular concentrations of the co-substrates NA and SAM and shunt more NA into the NAD+ salvage cycle

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In addition, it has been claimed to promote new vessel formation (28), upregulation of the growth factors, as well as influencing other local factors (46, 47)