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In addition to their cytotoxic effects, many small-molecule agents exhibit insufficient penetration into critical sanctuary sites, including granulomas, the blood-brain barrier (BBB), and various intracellular compartments, where pathogens can persist and facilitate relapse (Pardridge, 2020

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10.1186/s13041-017-0306-y 502 YolkenR.AdamosM.KatsafanasE.KhushalaniS.OrigoniA.SavageC.et al