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Aftereffects and “Tuesday Blues”: 1 to 3 Days Serotonin syndrome risk resolved, depletion begins: By 24 to 72 hours post-ingestion, the acute risk of serotonin toxicity has passed, but serotonergic neurons require days to replenish their depleted serotonin stores, producing the depressed mood, anxiety, fatigue, and cognitive fog colloquially called “Tuesday blues” when MDMA is used on weekends

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the dose is smaller as we use a smaller dose to begin with