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Normally, angiogenesis occurs during very specific times, such as development, reproduction, and wound healing, but it is also pivotal in the development of solid tumors and during their metastatic dissemination (Pallis 2013b)

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Recent studies have shown high levels of vitamin B12 in the pilosebaceous follicle, and demonstrated that Vit B12 supplementation in Propionibacterium acnes colonies promotes the production of porphyrins which undergo a process of oxidation on the skin surface, release pro-inflammatory substances that ultimately favor the development of acneiform lesions [7]