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Moreover, microglial activation is observed in in vitro and in vivo models using toxins such as MPTP, rotenone or 6-OHDA, as well as with lipopolysaccharide (LPS) [176–180]
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This explains why the COVID-19 pandemic has caused a significant increase in ME/CFS cases, as approximately 87% of patients who recover from acute infection with SARS-CoV-2 report symptoms similar to those of ME/CFS [15,16]
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