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Seven-week-old male C57BL6J WT and IAP global knockout (KO) ( Akp3 -/- ) mice (BSRC, Shizuoka, Japan) were housed in individual cages under environmentally controlled conditions (22 ± 2 °C and a 12-h light/dark cycle (8:00–20:00)) with ad libitum access to food and water

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