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Cytosolic mtDNA activates the cGAS-STING axis, driving type I interferon responses and pro-inflammatory cytokine production, whereas extracellular or endolysosomal mtDNA stimulates toll-like receptor 9 (TLR9), leading to NF-ΞΊB dependent inflammatory transcriptional programs
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doi: 10.1016/j.jiec.2017.06.050 114
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