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Methylglyoxal and methylglyoxal-derived AGE can further activate inflammatory cells by binding to RAGE

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NICE has appraised its use within specialist weight management services, subject to BMI and eligibility criteria [12] Liraglutide (Saxenda®) — another licensed GLP-1 receptor agonist available for weight management in adults, subject to MHRA-approved indications and prescribing criteria Orlistat (Xenical®/Alli®) — a lipase inhibitor available on NHS prescription and, at lower dose, over the counter Tirzepatide (Zepbound®) — a dual GIP/GLP-1 receptor agonist authorised by the MHRA specifically for chronic weight management in adults