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Certain probiotic strains direct mucosal immune activity by inducing the secretion of key cytokines and B-cell growth–promoting factors, including interleukin-4 (IL-4), interleukin-5 (IL-5), and interleukin-13 (IL-13) (215, 244)

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Furthermore, the functional studies associated with the CS were first described between 1888 and 1894, although evolutionarily, the CS is the most ancient component of the innate immune system, as a complement component called C3-like protein has existed a billion years ago (BYA) (166)