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In a randomized trial using PET-MRI to assess carotid plaque inflammation, semaglutide did not show a significant difference versus placebo on the prespecified primary plaque-inflammation endpoints—likely influenced by low baseline inflammatory burden in a well-treated population.⁹ How to interpret this: Imaging studies like this are helpful for understanding mechanisms and terminology (e.g., “atherosclerotic inflammation,” “PET-MRI plaque imaging”), but they do not establish semaglutide as a direct “vascular inflammation imaging reducer” in general clinical use based on current evidence.⁹ 5) They Improve Kidney Outcomes in High-Risk Populations (Semaglutide) By improving glycemic control and metabolic stress, GLP-1 therapies can reduce kidney risk in susceptible patients

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Pathogenesis of alcoholic liver disease: role of oxidative metabolism

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