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When assayed with ultrafiltered flavan-3,3,4-triol ( 4 ), oxidation of C13 in the wild-type enzyme resulted in a drastically lower formation of cyanidin ( 8 ), while we observed no effect for the C13S variant (Fig
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Furthermore, the tumor selectivity and potential off-target toxicity of agents such as Gboxin on normal lung epithelium remain unclear, posing challenges for clinical translation
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