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In contrast, the persulfidation of the critical cysteine in the peroxiredoxin Mt AhpE caused an increase in the reactivity with 4,4′-dithiodipyridine, which is not a substrate for the enzyme, but inhibited the reactivity towards the physiological substrates H 2 O 2 and peroxynitrite, when compared with the unmodified protein in the reduced state, due to alterations in the structure of the active site (Figure 2) (Cuevasanta et al., 2019)

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