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In its announcement, which came Friday afternoon, the FDA noted that safety and efficacy of Wegovy in the new indication were based on a trial comprising 17,600 patients randomized to receive either Novo’s drug or placebo, as well as standard medical treatment and lifestyle counseling

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The interactions between different PAIS building blocks strengthen the formation of a deep PAIS basin of attraction, i.e., a stabilized dyshomeostatic state (204, 325, 326)