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Current treatment guidelines for severe symptomatic chronic hyponatremia recommend empiric intervention with intravenous 3% NaCl to increase serum sodium levels by 4–6 mmol/L within the first 24 h 3,4,6,7,8,9

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When AOD-9604 binds to these receptors, it triggers a signaling cascade that increases cyclic adenosine monophosphate (cAMP), activates protein kinase A, and ramps up hormone-sensitive lipase activity